Phenotypes Associated with This Genotype

Genotype
MGI:3697482

• Allelic Composition: Atp1a1^tm1Ling/Atp1a1⁺
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to addictive substance ( J:117414 )

• increase in peak activity elicited by methamphetamine and prolonged habituation time

abnormal locomotor activation ( J:117414 )

• increased swimming speed during hidden platform training in a Morris water maze; however, latency to find the platform is not significantly different from wild-type

homeostasis/metabolism

increased circulating corticosterone level ( J:117414 )

• increase in basal and post methamphetamine challenge serum levels

• however, levels of norepinephrine, dopamine, serotonin, and their metabolites are all similar to wild-type mice