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Phenotypes Associated with This Genotype
Genotype
MGI:3697474
Allelic
Composition
Bin1tm1Gcp/Bin1tm2Gcp
Tg(MMTV-Myc)141-3Led/0
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bin1tm1Gcp mutation (0 available); any Bin1 mutation (10 available)
Bin1tm2Gcp mutation (1 available); any Bin1 mutation (10 available)
Tg(MMTV-Myc)141-3Led mutation (1 available)
Tg(Wap-cre)11738Mam mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

integument

neoplasm
• some mice develop aggressive lymphomas which occasionally appear before mammary carcinomas

cellular
• tumor cells show increased motility in monolayer culture
• tumor cells in culture show several fold greater resistance to serum deprivation-induced apoptosis
• tumor cells show 3-4 fold higher rates of proliferation under anchorage-dependent conditions

homeostasis/metabolism
• tumor cells have higher gelatinase activity

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:117730


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory