Mouse Genome Informatics
cn
    Bin1tm1Gcp/Bin1tm2Gcp
Tg(MMTV-Myc)141-3Led/0
Tg(Wap-cre)11738Mam/0

involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• some mice develop aggressive lymphomas which occasionally appear before mammary carcinomas

cellular
• tumor cells show increased motility in monolayer culture
• tumor cells in culture show several fold greater resistance to serum deprivation-induced apoptosis
• tumor cells show 3-4 fold higher rates of proliferation under anchorage-dependent conditions

homeostasis/metabolism
• tumor cells have higher gelatinase activity

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:117730