Phenotypes Associated with This Genotype

Genotype
MGI:3697422

• Allelic Composition: Tg(CAG-Aes,-ALPP)1Lbe/0; Tg(CAG-Tle1,-ALPP)1Lbe/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor susceptibility ( J:106684 )

• only 50% (6/12) double transgenic mice have visible tumors on the pleural surface compared to 96% (27/28) of Tg(ACTB-Tle1,-ALPP)1Lbe single transgenics at 6 months of age

• average number of visible tumors is 2.4 compared to 8.3 in single transgenic mice; tumors are substantially smaller in addition to being decreased in number

decreased lung tumor incidence ( J:106684 )

respiratory system

decreased lung tumor incidence ( J:106684 )