Phenotypes Associated with This Genotype

Genotype
MGI:3697420

• Allelic Composition: Tg(CAG-Tle1,-ALPP)1Lbe/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung adenocarcinoma incidence ( J:106684 )

• adults develop lung tumors with 100% penetrance

• neoplasms appear at 1 month resembling noninvasive bronchioalveolar carcinoma; at 3-5 months, visible tumor nodules are noted on the pleural surface with extensive proliferation, but preserving their bronchioalveolar growth pattern

• between 5 and 6 months, number of visible lesions on pleural surface increases from 3.2 to 8.3/mouse

• by 8 months, some lesions appear as whitish solid tumor masses characteristic of invasive cancer; such tumors replace large areas of lung parenchyma and show areas of necrosis

• tumor cells are tall columnar epithelial cells showing a mix of papillary, acinar, as well as bronchioalveolar growth patterns; there is prominent extracellular mucin secretion that causes destruction of alveolar septae

• alveolar and terminal bronchioles are lined with dysplastic epithelial cells with pleomorphic, enlarged ,irregular nuclei

respiratory system

increased lung adenocarcinoma incidence ( J:106684 )

• adults develop lung tumors with 100% penetrance

• neoplasms appear at 1 month resembling noninvasive bronchioalveolar carcinoma; at 3-5 months, visible tumor nodules are noted on the pleural surface with extensive proliferation, but preserving their bronchioalveolar growth pattern

• between 5 and 6 months, number of visible lesions on pleural surface increases from 3.2 to 8.3/mouse

• by 8 months, some lesions appear as whitish solid tumor masses characteristic of invasive cancer; such tumors replace large areas of lung parenchyma and show areas of necrosis

• tumor cells are tall columnar epithelial cells showing a mix of papillary, acinar, as well as bronchioalveolar growth patterns; there is prominent extracellular mucin secretion that causes destruction of alveolar septae

• alveolar and terminal bronchioles are lined with dysplastic epithelial cells with pleomorphic, enlarged ,irregular nuclei