Phenotypes for Atrx Tg(Gata1-cre)1Sho MGI:3696951 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Atrx^tm1Rjg/Atrx⁺ Tg(Gata1-cre)1Sho/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrx^tm1Rjg mutation (0 available); any Atrx mutation (78 available)
Tg(Gata1-cre)1Sho mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:115836 )

• fewer than expected found at E9.5; however, unlike hemizygous males some females do survive

reproductive system

abnormal reproductive system physiology ( J:115836 )

• some surviving females can reproduce

behavior/neurological

abnormal behavior ( J:115836 )

• surviving females display mild behavioral abnormalities

cellular

abnormal imprinting ( J:115836 )

• in surviving females expression of the paternal wild-type allele is seen in extraembryonic tissues; however, random X inactivation in the embryo is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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