Phenotypes Associated with This Genotype

Genotype
MGI:3696950

• Allelic Composition: Atrx^tm1Rjg/Y; Tg(Gata1-cre)1Sho/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:115836 )

♂ • the expected number of males are detected at E8.5 but fewer than expected are found at E9.5 and no males are found after E9.5

embryo

embryonic growth retardation ( J:115836 )

♂ • at E7.5

decreased embryo size ( J:115836 )

♂ • at E7.5

abnormal trophectoderm morphology ( J:115836 )

♂ • dramatic reduction in trophectoderm surrounding the embryo at E8.5

decreased trophoblast giant cell number ( J:115836 )

♂ • reduced numbers of terminally differentiated trophoblast giant cells at E7.5 and E8.5

♂ • defect is in formation of secondary trophoblast cells; however, development of primary cells is similar to wild-type

abnormal ectoplacental cone morphology ( J:115836 )

♂ • abnormally shaped at E8.5

small ectoplacental cone ( J:115836 )

♂ • reduced in size at E8.5

disorganized extraembryonic tissue ( J:115836 )

♂ • highly disorganized; however overall morphology of the embryonic tissues is similar to wild-type

growth/size/body

embryonic growth retardation ( J:115836 )

♂ • at E7.5

decreased embryo size ( J:115836 )

♂ • at E7.5

cellular

decreased cell proliferation ( J:115836 )

♂ • significant decrease in the number of mitotic cells at E7.5