Phenotypes Associated with This Genotype

Genotype
MGI:3696855

• Allelic Composition: Lmx1a^dr-10J/Lmx1a^dr-10J
• Genetic Background: 129P3/J-Lmx1a^dr-10J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Smaller size and shortened tail in a Lmx1a^dr-10J/Lmx1a^dr-10J mouse (top) compared with a normal littermate (bottom)

hearing/vestibular/ear

abnormal ear development ( J:128476 )

abnormal inner ear morphology ( J:128476 )

• the inner ear is reduced in overall size

abnormal cochlea morphology ( J:128476 )

• cochlea is found to be shortened and lacking compartmentalization

abnormal semicircular canal morphology ( J:128476 )

• undeveloped semicircular canals

abnormal membranous labyrinth morphology ( J:128476 )

• Histology at 30 weeks of age shows that the membranous labyrinths are not developed

absent utricle ( J:128476 )

absent vestibular saccule ( J:128476 )

abnormal cochlear labyrinth morphology ( J:128476 )

• cochlea is not formed

increased or absent threshold for auditory brainstem response ( J:128476 )

• ABR assessment reveals deafness

syndromic hearing loss ( J:128476 )

nervous system

reduced cerebellar foliation ( J:128476 )

• cerebellar foliation is reduced compared with that of littermate controls

decreased brain size ( J:128476 )

behavior/neurological

head tossing ( J:128476 )

bidirectional circling ( J:128476 )

limbs/digits/tail

short tail ( J:128476 )

kinked tail ( J:128476 )

• some, but not all, mutants have tail kinks

growth/size/body

decreased body size ( J:128476 )

• slightly smaller body size than normal littermates

reproductive system

abnormal fertility/fecundity ( J:128476 )

♂ • some mutant males never breed although females do