Phenotypes Associated with This Genotype

Genotype
MGI:3696844

• Allelic Composition: Cib1^tm1Prse/Cib1^tm1Prse
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased testis weight ( J:114645 )

♂ • weight of testis at 3-4 months of age is about 47.5% that of controls

abnormal spermatogenesis ( J:114645 )

♂ • spermatogonia, spematocytes, and round spermatids are present in the testis; however, seminiferous tubules lack advanced spermatids, have multinucleated spermatids near the tubule lumen and no sperm are found in the epididymis

♂ • increase in spermatid apoptosis in the testis

azoospermia ( J:114645 )

♂ • sperm production is undetectable in the epididymis

abnormal spermiogenesis ( J:114645 )

♂ • disruption of the haploid phase of germ cell differentiation

arrest of spermatogenesis ( J:114645 )

♂ • spermatogenic cells complete both mitotic and meiotic divisions, however postmeiotic spermatids do not develop normally and sperm are not produced

male infertility ( J:114645 )

♂ • males are sterile due to disruption of the haploid phase of spermatogenesis

endocrine/exocrine glands

decreased testis weight ( J:114645 )

♂ • weight of testis at 3-4 months of age is about 47.5% that of controls

cellular

azoospermia ( J:114645 )

♂ • sperm production is undetectable in the epididymis

decreased cell proliferation ( J:114645 )

• MEFs exhibit a slower growth rate