Phenotypes Associated with This Genotype

Genotype
MGI:3696836

• Allelic Composition: Mcm4^chaos3/Mcm4^{Gt(RRE056)Byg}
• Genetic Background: B6.Cg-Mcm4^chaos3 Mcm4^{Gt(RRE056)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:117494 )

• embryos are found until E14.5

• Background Sensitivity: on mixed backgrounds, mutants show extended survival

embryo

embryonic growth retardation ( J:117494 )

• majority are growth retarded

growth/size/body

embryonic growth retardation ( J:117494 )

• majority are growth retarded

cellular

abnormal cell cycle ( J:117494 )

• there are a lower number of cells in S phase and slightly increased G2/M populations compared to controls

decreased fibroblast proliferation ( J:117494 )

• mouse embryonic fibroblasts (MEFs) show a mild defect in proliferation

induced chromosome breakage ( J:117494 )

• MEFs are highly susceptible to aphidicolin-induced chromosome breaks