Phenotypes Associated with This Genotype

Genotype
MGI:3696835

• Allelic Composition: Mcm4^chaos3/Mcm4^chaos3
• Genetic Background: C3.B6-Mcm4^chaos3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:117494 )

• females (majority are virgin) show a high susceptibility to development of mammary tumors

increased mammary adenocarcinoma incidence ( J:117494 )

• 13/16 females develop mammary tumors with a latency of 12 months; five animals had more than one tumor

• 9/18 tumors were in thoracic mammary gland and 7/18 were in cervical mammary gland

increased hepatocellular carcinoma incidence ( J:117494 )

• 1 female developed a hepatocellular carcinoma

increased lung adenocarcinoma incidence ( J:117494 )

• 2 mammary tumors metastasized to lung

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:117494 )

• females (majority are virgin) show a high susceptibility to development of mammary tumors

increased mammary adenocarcinoma incidence ( J:117494 )

• 13/16 females develop mammary tumors with a latency of 12 months; five animals had more than one tumor

• 9/18 tumors were in thoracic mammary gland and 7/18 were in cervical mammary gland

respiratory system

increased lung adenocarcinoma incidence ( J:117494 )

• 2 mammary tumors metastasized to lung

liver/biliary system

increased hepatocellular carcinoma incidence ( J:117494 )

• 1 female developed a hepatocellular carcinoma

integument

increased mammary gland tumor incidence ( J:117494 )

• females (majority are virgin) show a high susceptibility to development of mammary tumors

increased mammary adenocarcinoma incidence ( J:117494 )

• 13/16 females develop mammary tumors with a latency of 12 months; five animals had more than one tumor

• 9/18 tumors were in thoracic mammary gland and 7/18 were in cervical mammary gland