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Phenotypes Associated with This Genotype
Genotype
MGI:3696576
Allelic
Composition
Tg(Prnp-App/APPswe)E1-2Dbo/0
Genetic
Background
B6.C3-Tg(Prnp-App/APPswe)E1-2Dbo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-App/APPswe)E1-2Dbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 14-15 month old mutants backcrossed 5- or 10 generations tend to have higher accumulation of amyloid compared to Tg(APP695)3Dbo at that age

behavior/neurological
• as females age (13-14 months of age), significant difference compared to female controls is observed in trials with longest (<60 minute) delays
• 12-13 month old males and females backcrossed 5-7 generations show poorer performance in probe trials in the Morris water maze; females spent less time in correct quadrant until fourth consectutive session
• upon repeat testing of the same females one month later, difference between mutants and controls is more robust; repeated testing had no effect on performance
• at 12-13 months, females backcrossed 5-7 generations are less active in visiting open arms in plus maze; combined with reduced rearing reactions, females may have higher anxiety levels
• in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task
• at 12-13 months, mice backcrossed 5-7 generations show fewer rearing reactions compared to nontransgenic littermates
• at 12-13 months, males backcrossed 5-7 generations are less active than controls in inner cells of open field

homeostasis/metabolism
• 14-15 month old mutants backcrossed 5- or 10 generations tend to have higher accumulation of amyloid compared to Tg(APP695)3Dbo at that age

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:109847


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/21/2017
MGI 6.07
The Jackson Laboratory