Mouse Genome Informatics
tg
    Tg(Prnp-App/APPswe)E1-2Dbo/0
B6.C3-Tg(Prnp-App/APPswe)E1-2Dbo
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• 14-15 month old mutants backcrossed 5- or 10 generations tend to have higher accumulation of amyloid compared to Tg(APP695)3Dbo at that age

behavior/neurological
• at 12-13 months, females backcrossed 5-7 generations are less active in visiting open arms in plus maze; combined with reduced rearing reactions, females may have higher anxiety levels
• as females age (13-14 months of age), significant difference compared to female controls is observed in trials with longest (<60 minute) delays
• 12-13 month old males and females backcrossed 5-7 generations show poorer performance in probe trials in the Morris water maze; females spent less time in correct quadrant until fourth consectutive session
• upon repeat testing of the same females one month later, difference between mutants and controls is more robust; repeated testing had no effect on performance
• in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task
• at 12-13 months, mice backcrossed 5-7 generations show fewer rearing reactions compared to nontransgenic littermates
• at 12-13 months, males backcrossed 5-7 generations are less active than controls in inner cells of open field

homeostasis/metabolism
• 14-15 month old mutants backcrossed 5- or 10 generations tend to have higher accumulation of amyloid compared to Tg(APP695)3Dbo at that age

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:109847