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Phenotypes Associated with This Genotype
Genotype
MGI:3696576
Allelic
Composition
Tg(Prnp-App/APPswe)E1-2Dbo/0
Genetic
Background
B6.C3-Tg(Prnp-App/APPswe)E1-2Dbo
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 14-15 month old mutants backcrossed 5- or 10 generations tend to have higher accumulation of amyloid compared to Tg(APP695)3Dbo at that age

behavior/neurological
• as females age (13-14 months of age), significant difference compared to female controls is observed in trials with longest (<60 minute) delays
• 12-13 month old males and females backcrossed 5-7 generations show poorer performance in probe trials in the Morris water maze; females spent less time in correct quadrant until fourth consectutive session
• upon repeat testing of the same females one month later, difference between mutants and controls is more robust; repeated testing had no effect on performance
• at 12-13 months, females backcrossed 5-7 generations are less active in visiting open arms in plus maze; combined with reduced rearing reactions, females may have higher anxiety levels
• in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task
• at 12-13 months, mice backcrossed 5-7 generations show fewer rearing reactions compared to nontransgenic littermates
• at 12-13 months, males backcrossed 5-7 generations are less active than controls in inner cells of open field

homeostasis/metabolism
• 14-15 month old mutants backcrossed 5- or 10 generations tend to have higher accumulation of amyloid compared to Tg(APP695)3Dbo at that age

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:109847


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory