Phenotypes Associated with This Genotype

Genotype
MGI:3696446

• Allelic Composition: Grhl3^tm1Bogi/Grhl3^tm1Bogi; Lmo4^tm1.1Gng/Lmo4^tm1.1Gng
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

spina bifida ( J:114626 )

• 100% exhibit spina bifida

exencephaly ( J:114626 )

• 100% show exencepahly

vision/eye

eyelids open at birth ( J:114626 )

• 54% show open eyes at birth

limbs/digits/tail

curly tail ( J:114626 )

• 100% exhibit curly tail

embryo

spina bifida ( J:114626 )

• 100% exhibit spina bifida

integument

abnormal epidermal layer morphology ( J:114626 )

• exhibit an enhanced epidermis terminal differentiation defect than seen in single Grhl3 homozygotes

abnormal epidermis stratum corneum morphology ( J:114626 )

• skin shows impaired stratum corneum formation with most cells in the top of the epidermis containing nuclei; many cells show enlarged vacuolar-like structure not normally found in the granular layer

• the stratum corneum abnormality is primarily found at the anterior part of the embryo in the skin covering the head and upper body regions

abnormal corneocyte envelope morphology ( J:114626 )

• cornified envelopes are essentially absent

cellular

abnormal corneocyte envelope morphology ( J:114626 )

• cornified envelopes are essentially absent