Analysis Tools
nervous system
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• mice exhibit a progressive neuronal atrophy that is most pronounced in the granule cell layer of hippocampal dentate gyrus
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• mice exhibit a progressive neuronal atrophy that is most pronounced in the granule cell layer of hippocampal dentate gyrus
• however, when mice are reared on doxycycline, cell loss is not observed
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• mice produce transgenic APP protein at 10- to 30-fold over endogenous App levels
• expression of APPSw/Ind is higher relative to other three double transgenic lines, and suprression requires more doxycycline than the other three lines
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homeostasis/metabolism
