Phenotypes Associated with This Genotype

Genotype
MGI:3696381

• Allelic Composition: Otx1^tm1Sia/Otx1⁺; Otx2^tm2(Otx1)Sia/Otx2⁺
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased rhombomere 1 size ( J:51989 )

• majority of E10.5 embryos show slightly expanded rhombomere 1

abnormal midbrain-hindbrain boundary morphology ( J:51989 )

• majority of E10.5 embryos show a somewhat extended isthmic constriction

decreased midbrain size ( J:51989 )

• majority of E10.5 embryos show a smaller mesencephalon

• however, sulcus telodiencephalicus is present normally and no defects are seen in telencephalon or diencephalons

embryo

increased rhombomere 1 size ( J:51989 )

• majority of E10.5 embryos show slightly expanded rhombomere 1