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Phenotypes Associated with This Genotype
Genotype
MGI:3696381
Allelic
Composition		 Otx1tm1Sia/Otx1+
Otx2tm2(Otx1)Sia/Otx2+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1tm1Sia mutation (1 available); any Otx1 mutation (86 available)
Otx2tm2(Otx1)Sia mutation (0 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased rhombomere 1 size ( J:51989 )
• majority of E10.5 embryos show slightly expanded rhombomere 1
abnormal midbrain-hindbrain boundary morphology ( J:51989 )
• majority of E10.5 embryos show a somewhat extended isthmic constriction
decreased midbrain size ( J:51989 )
• majority of E10.5 embryos show a smaller mesencephalon
• however, sulcus telodiencephalicus is present normally and no defects are seen in telencephalon or diencephalons

embryo
increased rhombomere 1 size ( J:51989 )
• majority of E10.5 embryos show slightly expanded rhombomere 1

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory