Phenotypes Associated with This Genotype

Genotype
MGI:3696349

• Allelic Composition: Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^tm2Jmch
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cutaneous phenotypes of Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} and Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^tm2Jmch mice

mortality/aging

mortality/aging ( J:116054 )

N • normal lifespan unlike Ercc2^{tm2(ERCC2)Jhjh} homozygotes

growth/size/body

growth/size/body region phenotype ( J:116054 )

N • full rescue of age-related cachexia that is seen in Ercc2^{tm2(ERCC2)Jhjh} homozygotes

postnatal growth retardation ( J:116054 )

• partial rescue of developmental delay compared to Ercc2^{tm2(ERCC2)Jhjh} homozygotes

hematopoietic system

anemia ( J:116054 )

• partially rescued compared to Ercc2^{tm2(ERCC2)Jhjh} homozygotes

skeleton

skeleton phenotype ( J:116054 )

N • mice do not develop osteoporosis or kyphosis any earlier than wild-type mice

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:116054 )

• UV sensitivity is less than in Ercc2^{tm2(ERCC2)Jhjh} homozygotes

integument

integument phenotype ( J:116054 )

N • absence of acanthosis, hyperkeratosis, and granular layer and sebacious gland hyperplasia

focal dorsal hair loss ( J:116054 )

• only seen during the first hair cycle and only locally on the back

brittle hair ( J:116054 )

• less severe than in Ercc2^{tm2(ERCC2)Jhjh} homozygotes

• only a very low frequency of broken hairs