Phenotypes Associated with This Genotype

Genotype
MGI:3696347

• Allelic Composition: Ercc2^tm1Jmch/Ercc2^{tm2(ERCC2)Jhjh}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:116054 )

N • normal lifespan unlike Ercc2^{tm2(ERCC2)Jhjh} homozygotes

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:116054 )

• UV sensitivity is less than in Ercc2^{tm2(ERCC2)Jhjh} Ercc2^tm1Jhjh compound heterozygotes

• decrease in UV sensitivity is not as large as in Ercc2^{tm2(ERCC2)Jhjh} Ercc2^tm2Jmch compound heterozygotes

growth/size/body

growth/size/body region phenotype ( J:116054 )

N • full rescue of age-related cachexia that is seen in Ercc2^{tm2(ERCC2)Jhjh} homozygotes

integument

focal dorsal hair loss ( J:116054 )

• only seen during the first hair cycle and only locally on the back