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Phenotypes Associated with This Genotype
Genotype
MGI:3696122
Allelic
Composition		 Igf1tm1Arge/Igf1+
Genetic
Background		 involves: 129S/SvEv * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm1Arge mutation (2 available); any Igf1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
small cochlear ganglion ( J:71687 )
• at P20 (but not P5), heterozygotes display a moderate reduction in cochlear ganglion volume (10%) and in neuronal size (12%) relative to wild-type mice

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:105536 )
N
• at 3 months, heterozygotes display no significant differences in click-ABR thresholds and interpeak I-IV latencies relative to wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory