Analysis Tools
mortality/aging
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• by 10 weeks of age, mice become ill; 90% are moribund by 200 days
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growth/size/body
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• young adults (males - 15.4 grams, females - 14.4 grams) are smaller than controls (males - 24 grams, females - 18 grams)
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homeostasis/metabolism
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• serum has excessive levels of creatinine compared to controls( 200 mol/l vs 47 mmol/l)
|
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• serum has excessive levels of urea compared to controls (169 mmol/l vs 9 mmol/l)
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albuminuria
(
J:115272
)
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• mice have high levels of albumin in urine from early ages
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renal/urinary system
albuminuria
(
J:115272
)
|
• mice have high levels of albumin in urine from early ages
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• kidneys show inflammatory infiltration
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• affected foci show infiltrating inflammatory cells
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• structure is 2-4 cell layers thick compared to 1 layer in wild-type
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• kidneys display lesions affecting clusters of glomeruli and their proximal tubules
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• kidneys show glomerular loss
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• kidneys display cortical atrophy
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• kidneys display lesions affecting clusters of glomeruli and their proximal tubules
• these show fatty degeneration and contain protein casts
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renal cast
(
J:115272
)
|
• affected proximal tubules contain protein casts
|
hematopoietic system
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• generation of platelets in mutants is slower than in wild-type
|
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• homozygotes have platelet counts only 40% of those in wild-type
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• volume is 10.0 fl for mutant platelets compared to 8.4 fl for wild-type
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immune system
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• generation of platelets in mutants is slower than in wild-type
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• kidneys show inflammatory infiltration
|
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• affected foci show infiltrating inflammatory cells
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