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Phenotypes Associated with This Genotype
Genotype
MGI:3696110
Allelic
Composition		 Tg(Nlrp1b)1Die/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nlrp1b)1Die mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:99748 )
• transgenic bone marrow-derived macrophages are fully susceptible to necrosis induction by lethal toxin (LeTx) derived from B. anthracis, whereas macrophages from non-transgenic littermates are resistant

hematopoietic system
abnormal macrophage physiology ( J:99748 )
• transgenic bone marrow-derived macrophages are fully susceptible to necrosis induction by lethal toxin (LeTx) derived from B. anthracis, whereas macrophages from non-transgenic littermates are resistant

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory