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Phenotypes Associated with This Genotype
Genotype
MGI:3696026
Allelic
Composition		 Akap8Gt(XG068)Byg/Akap8Gt(XG068)Byg
Fignfi/Fignfi
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap8Gt(XG068)Byg mutation (0 available); any Akap8 mutation (43 available)
Fignfi mutation (2 available); any Fign mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cleft palate in Akap8Gt(XG068)Byg/Akap8Gt(XG068)Byg Fignfi/Fignfi mice

mortality/aging
postnatal lethality, complete penetrance ( J:116474 )
• surviving mutants are generally smaller than littermates, do not nurse well, and gradually die prior to weaning, with very few surviving to 3 weeks (3/258)
neonatal lethality, incomplete penetrance ( J:116474 )
• double mutants survive through birth, but ~50% die within a few hours of birth

craniofacial
cleft secondary palate ( J:116474 )
• 50% of newborns show complete cleft of the secondary palate

respiratory system
respiratory distress ( J:116474 )
• some newborns display gasping

digestive/alimentary system
cleft secondary palate ( J:116474 )
• 50% of newborns show complete cleft of the secondary palate

homeostasis/metabolism
cyanosis ( J:116474 )
• some newborns retain blue skin color (exhibit cyanosis) prior to death

growth/size/body
cleft secondary palate ( J:116474 )
• 50% of newborns show complete cleft of the secondary palate

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory