Phenotypes Associated with This Genotype

Genotype
MGI:3695940

• Allelic Composition: Notch1^tm1Grid/Notch1⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina blood vessel morphology ( J:227333 )

• increase in vessel density in retinas at P5

• retinal capillaries exhibit gaps in pericyte coverage

hearing/vestibular/ear

increased cochlear outer hair cell number ( J:62727 )

• at P1, neonatal heterozygotes display numerous regions of the cochlear sensory epithelium with 4 rather than 3 rows of OHCs

• significant increases are noted in both the numbers of regions of fourth row OHCs, as well as the total number of fourth row OHCs

• however, patterning of OHC rows is normal, and no supernumerary hair cells are observed in the IHC row

vision/eye

abnormal retina blood vessel morphology ( J:227333 )

• increase in vessel density in retinas at P5

• retinal capillaries exhibit gaps in pericyte coverage

nervous system

increased cochlear outer hair cell number ( J:62727 )

• at P1, neonatal heterozygotes display numerous regions of the cochlear sensory epithelium with 4 rather than 3 rows of OHCs

• significant increases are noted in both the numbers of regions of fourth row OHCs, as well as the total number of fourth row OHCs

• however, patterning of OHC rows is normal, and no supernumerary hair cells are observed in the IHC row