Phenotypes Associated with This Genotype

Genotype
MGI:3695923

• Allelic Composition: Amelx^tm2Msnd/Amelx^tm2Msnd
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enamel architecture changes in Amelx^tm1Msnd/Amelx^tm1Msnd and Amelx^tm2Msnd/Amelx^tm2Msnd mice

craniofacial

abnormal molar crown morphology ( J:116448 )

♀ • accelerated wear

abnormal enamel morphology ( J:116448 )

♀ • amelogenin nanospheres are larger than in wild-type mice

♀ • enamel crystallites have irregular size and organization

abnormal ameloblast morphology ( J:116448 )

♀ • Tomes' processes are shorter and alpha 6 integrin expression is distributed at multiple foci in the secretory end piece

short Tomes' process ( J:116448 )

♀ • Tomes' processes are shorter

abnormal enamel rod pattern ( J:116448 )

♀ • arrangement and size of rods are abnormal

♀ • weaving of the matrix is reduced

reduced enamel thickness ( J:116448 )

♀ • reduced thickness and more easily abraded

abnormal tooth wear ( J:116448 )

♀ • molars show accelerated wear

♀ • enamel is more prone to fracture and more easily abraded with mastication

brittle teeth ( J:116448 )

♀ • incisors are fragile with incisal edge fractures during chewing

skeleton

abnormal molar crown morphology ( J:116448 )

♀ • accelerated wear

abnormal enamel morphology ( J:116448 )

♀ • amelogenin nanospheres are larger than in wild-type mice

♀ • enamel crystallites have irregular size and organization

abnormal ameloblast morphology ( J:116448 )

♀ • Tomes' processes are shorter and alpha 6 integrin expression is distributed at multiple foci in the secretory end piece

short Tomes' process ( J:116448 )

♀ • Tomes' processes are shorter

abnormal enamel rod pattern ( J:116448 )

♀ • arrangement and size of rods are abnormal

♀ • weaving of the matrix is reduced

reduced enamel thickness ( J:116448 )

♀ • reduced thickness and more easily abraded

abnormal tooth wear ( J:116448 )

♀ • molars show accelerated wear

♀ • enamel is more prone to fracture and more easily abraded with mastication

brittle teeth ( J:116448 )

♀ • incisors are fragile with incisal edge fractures during chewing

growth/size/body

abnormal molar crown morphology ( J:116448 )

♀ • accelerated wear

abnormal enamel morphology ( J:116448 )

♀ • amelogenin nanospheres are larger than in wild-type mice

♀ • enamel crystallites have irregular size and organization

abnormal ameloblast morphology ( J:116448 )

♀ • Tomes' processes are shorter and alpha 6 integrin expression is distributed at multiple foci in the secretory end piece

short Tomes' process ( J:116448 )

♀ • Tomes' processes are shorter

abnormal enamel rod pattern ( J:116448 )

♀ • arrangement and size of rods are abnormal

♀ • weaving of the matrix is reduced

reduced enamel thickness ( J:116448 )

♀ • reduced thickness and more easily abraded

abnormal tooth wear ( J:116448 )

♀ • molars show accelerated wear

♀ • enamel is more prone to fracture and more easily abraded with mastication

brittle teeth ( J:116448 )

♀ • incisors are fragile with incisal edge fractures during chewing