Phenotypes Associated with This Genotype

Genotype
MGI:3695921

• Allelic Composition: Amelx^tm1Msnd/Amelx^tm1Msnd
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enamel architecture changes in Amelx^tm1Msnd/Amelx^tm1Msnd and Amelx^tm2Msnd/Amelx^tm2Msnd mice

craniofacial

abnormal molar cusp morphology ( J:116448 )

♀ • 6-week molars display a shallow cusp structure

abnormal enamel morphology ( J:116448 )

♀ • at 4 days of age, 15-20 nm nanospheres of amelogenin are absent

abnormal ameloblast morphology ( J:116448 )

♀ • Tomes' processes are shorter and alpha 6 integrin expression is restricted to the flat apical membrane

short Tomes' process ( J:116448 )

♀ • Tomes' processes are shorter

abnormal enamel rod pattern ( J:116448 )

♀ • lack woven rods of crystallites

♀ • rod organization is disrupted and rod and interrod boundary features are absent

reduced enamel thickness ( J:116448 )

♀ • reduced thickness and more easily abraded

abnormal tooth wear ( J:116448 )

♀ • enamel is more prone to fracture and more easily abraded with mastication

brittle teeth ( J:116448 )

♀ • incisors fracture during chewing

♀ • enamel is more prone to fracture

skeleton

abnormal molar cusp morphology ( J:116448 )

♀ • 6-week molars display a shallow cusp structure

abnormal enamel morphology ( J:116448 )

♀ • at 4 days of age, 15-20 nm nanospheres of amelogenin are absent

abnormal ameloblast morphology ( J:116448 )

♀ • Tomes' processes are shorter and alpha 6 integrin expression is restricted to the flat apical membrane

short Tomes' process ( J:116448 )

♀ • Tomes' processes are shorter

abnormal enamel rod pattern ( J:116448 )

♀ • lack woven rods of crystallites

♀ • rod organization is disrupted and rod and interrod boundary features are absent

reduced enamel thickness ( J:116448 )

♀ • reduced thickness and more easily abraded

abnormal tooth wear ( J:116448 )

♀ • enamel is more prone to fracture and more easily abraded with mastication

brittle teeth ( J:116448 )

♀ • incisors fracture during chewing

♀ • enamel is more prone to fracture

growth/size/body

abnormal molar cusp morphology ( J:116448 )

♀ • 6-week molars display a shallow cusp structure

abnormal enamel morphology ( J:116448 )

♀ • at 4 days of age, 15-20 nm nanospheres of amelogenin are absent

abnormal ameloblast morphology ( J:116448 )

♀ • Tomes' processes are shorter and alpha 6 integrin expression is restricted to the flat apical membrane

short Tomes' process ( J:116448 )

♀ • Tomes' processes are shorter

abnormal enamel rod pattern ( J:116448 )

♀ • lack woven rods of crystallites

♀ • rod organization is disrupted and rod and interrod boundary features are absent

reduced enamel thickness ( J:116448 )

♀ • reduced thickness and more easily abraded

abnormal tooth wear ( J:116448 )

♀ • enamel is more prone to fracture and more easily abraded with mastication

brittle teeth ( J:116448 )

♀ • incisors fracture during chewing

♀ • enamel is more prone to fracture