Phenotypes for Ctsk Ctsl MGI:3695741 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ctsk^tm1Psa/Ctsk^tm1Psa Ctsl^tm1Cptr/Ctsl^tm1Cptr
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsk^tm1Psa mutation (1 available); any Ctsk mutation (31 available)
Ctsl^tm1Cptr mutation (2 available); any Ctsl mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:83877 )

• cells with enlarged lysosomes

abnormal thyroid follicle morphology ( J:83877 )

• 80% increase in size over controls

homeostasis/metabolism

abnormal thyroid hormone level ( J:83877 )

• 5-6 fold increases in thyroglobulin levels

decreased thyroxine level ( J:83877 )

• significantly reduced levels of free T4

decreased circulating thyroxine level ( J:83877 )

• deficient serum levels of T4

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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