Phenotypes for Ctsk Ctsl MGI:3695741 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Ctsk^tm1Psa/Ctsk^tm1Psa Ctsl^tm1Cptr/Ctsl^tm1Cptr
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsk^tm1Psa mutation (1 available); any Ctsk mutation (30 available)
Ctsl^tm1Cptr mutation (2 available); any Ctsl mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:83877 )

• cells with enlarged lysosomes

abnormal thyroid follicle morphology ( J:83877 )

• 80% increase in size over controls

homeostasis/metabolism

abnormal thyroid hormone level ( J:83877 )

• 5-6 fold increases in thyroglobulin levels

decreased thyroxine level ( J:83877 )

• significantly reduced levels of free T4

decreased circulating thyroxine level ( J:83877 )

• deficient serum levels of T4

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24