Phenotypes Associated with This Genotype

Genotype
MGI:3695716

• Allelic Composition: Ldlr^tm1(LDLR)Mae/Ldlr⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating lipid level ( J:67282 )

• decrease in plasma lipid levels that is accompanied by reduction in plasma apoproteins B, E, and AI

decreased circulating cholesterol level ( J:67282 )

• females exhibit a 4-fold reduction in steady state plasma cholesterol when fed normal chow

• when fed a high fat diet, plasma cholesterol levels increase due mainly to the increase in HDL cholesterol, although levels are still lower than in wild-type on a high fat diet

decreased circulating HDL cholesterol level ( J:67282 )