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Phenotypes Associated with This Genotype
Genotype
MGI:3695610
Allelic
Composition
Satb2tm1(cre)Vit/Satb2+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Satb2tm1(cre)Vit mutation (0 available); any Satb2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer found at weaning than expected (about 35% compared to the expected 50%)

craniofacial
• at E11.5 a variable increase in apoptosis is seen in the mandibular BA1, maxillary BA1, and frontonasal mesenchyme regions that normally express Satb2
• variable incisor hypodontia and or adontia
• seen in about 1/4 of mice
• small
• strongly truncated and occasionally asymmetric

respiratory system

skeleton
• at E11.5 a variable increase in apoptosis is seen in the mandibular BA1, maxillary BA1, and frontonasal mesenchyme regions that normally express Satb2
• variable incisor hypodontia and or adontia

digestive/alimentary system
• seen in about 1/4 of mice

growth/size/body
• variable incisor hypodontia and or adontia
• seen in about 1/4 of mice
• small
• strongly truncated and occasionally asymmetric
• slight

Mouse Models of Human Disease
OMIM ID Ref(s)
Cleft Palate, Isolated; CPI 119540 J:116770


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory