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Phenotypes Associated with This Genotype
Genotype
MGI:3695610
Allelic
Composition
Satb2tm1(cre)Vit/Satb2+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Satb2tm1(cre)Vit mutation (0 available); any Satb2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer found at weaning than expected (about 35% compared to the expected 50%)

craniofacial
• at E11.5 a variable increase in apoptosis is seen in the mandibular BA1, maxillary BA1, and frontonasal mesenchyme regions that normally express Satb2
• variable incisor hypodontia and or adontia
• seen in about 1/4 of mice
• small mouth
• snout is occasionally asymmetric
• snout is strongly truncated

respiratory system

skeleton
• at E11.5 a variable increase in apoptosis is seen in the mandibular BA1, maxillary BA1, and frontonasal mesenchyme regions that normally express Satb2
• variable incisor hypodontia and or adontia

digestive/alimentary system
• seen in about 1/4 of mice

growth/size/body
• variable incisor hypodontia and or adontia
• seen in about 1/4 of mice
• small mouth
• snout is occasionally asymmetric
• snout is strongly truncated
• slight

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
isolated cleft palate DOID:0110213 OMIM:119540
J:116770


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory