Phenotypes Associated with This Genotype

Genotype
MGI:3695609

• Allelic Composition: Satb2^tm1(cre)Vit/Satb2^tm1(cre)Vit
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:116770 )

craniofacial

abnormal hyoid bone morphology ( J:116770 )

• malformed

abnormal jaw morphology ( J:116770 )

• the mesenchymal component of the jaw that normally expresses Satb2 fails to elaborate during development

• midline structures form, while parasagital elements (i.e. incisors and associated alveolar bone) fail to form

• at E10.5, initial patterning of the jaw appears similar to wild-type; however by E11.5 increased apoptosis is seen in the mandibular BA1, maxillary BA1, and frontonasal mesenchyme regions that normally express Satb2

absent incisors ( J:116770 )

• fully penetrant

abnormal molar morphology ( J:116770 )

• variable enlargement of the molar dental buds and these enlarged buds contain elaborate epithelial folds

premaxilla hypoplasia ( J:116770 )

• hypoplasia is more severe than in heterozygotes

micrognathia ( J:116770 )

abnormal nasal capsule morphology ( J:116770 )

• hypoplasia is more severe than in heterozygotes

cleft palate ( J:116770 )

• fully penetrant

decreased tongue size ( J:116770 )

• severe

respiratory system

abnormal nasal capsule morphology ( J:116770 )

• hypoplasia is more severe than in heterozygotes

digestive/alimentary system

cleft palate ( J:116770 )

• fully penetrant

decreased tongue size ( J:116770 )

• severe

absent submandibular gland ( J:116770 )

• fail to form

limbs/digits/tail

short limbs ( J:116770 )

endocrine/exocrine glands

absent submandibular gland ( J:116770 )

• fail to form

skeleton

abnormal hyoid bone morphology ( J:116770 )

• malformed

abnormal jaw morphology ( J:116770 )

• the mesenchymal component of the jaw that normally expresses Satb2 fails to elaborate during development

• midline structures form, while parasagital elements (i.e. incisors and associated alveolar bone) fail to form

• at E10.5, initial patterning of the jaw appears similar to wild-type; however by E11.5 increased apoptosis is seen in the mandibular BA1, maxillary BA1, and frontonasal mesenchyme regions that normally express Satb2

absent incisors ( J:116770 )

• fully penetrant

abnormal molar morphology ( J:116770 )

• variable enlargement of the molar dental buds and these enlarged buds contain elaborate epithelial folds

premaxilla hypoplasia ( J:116770 )

• hypoplasia is more severe than in heterozygotes

micrognathia ( J:116770 )

abnormal nasal capsule morphology ( J:116770 )

• hypoplasia is more severe than in heterozygotes

growth/size/body

absent incisors ( J:116770 )

• fully penetrant

abnormal molar morphology ( J:116770 )

• variable enlargement of the molar dental buds and these enlarged buds contain elaborate epithelial folds

abnormal nasal capsule morphology ( J:116770 )

• hypoplasia is more severe than in heterozygotes

cleft palate ( J:116770 )

• fully penetrant

decreased tongue size ( J:116770 )

• severe

microcephaly ( J:116770 )

• more severe than in heterozygotes