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Phenotypes Associated with This Genotype
Genotype
MGI:3695608
Allelic
Composition
Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndfip1Gt(RRD002)Byg mutation (0 available); any Ndfip1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die shortly after weaning
• dramatic decrease in survival beginning around 10 weeks of age with no mice survive more than 14 weeks

immune system
• spleen to body weight ratio is 16.9 +/- 2.7 mg/g compared to 3.4 +/- 0.5 mg/g in wild-type mice
• more T cells express CD4 and are activated
• following TCR stimulation; however, in the absence of stimulation cells do not divide (similar to wild-type cells)
• in Th2-polarizing conditions T cells are more likely to produce IL-4 compared to wild-type cells
• signs of inflammation including goblet cell hyperplasia and inflammatory infiltrate in perivascular regions
• by 6 weeks of age some mice develop skin lesions on their ears and by 8 weeks of age all mice have these lesions
• inflammation contains a predominantly eosinophilic and lymphocytic inflitrate

hematopoietic system
• spleen to body weight ratio is 16.9 +/- 2.7 mg/g compared to 3.4 +/- 0.5 mg/g in wild-type mice
• seen in the liver and spleen
• bone marrow contains fewer B cells, more myeloid lineage cells, and similar numbers of pre-erythroid cells compared to wild-type mice
• more T cells express CD4 and are activated
• following TCR stimulation; however, in the absence of stimulation cells do not divide (similar to wild-type cells)
• in Th2-polarizing conditions T cells are more likely to produce IL-4 compared to wild-type cells

liver/biliary system
• intrahepatic bile ducts
• intrahepatic bile ducts
• liver to body weight ratio is 101 +/- 11 mg/g compared to 48 +/- 4 mg/g in wild-type mice

limbs/digits/tail
• tail becomes segmented in appearance over time
• tails tend to be shorter

growth/size/body
• develops shortly after the appearance of skin lesions
• liver to body weight ratio is 101 +/- 11 mg/g compared to 48 +/- 4 mg/g in wild-type mice
• spleen to body weight ratio is 16.9 +/- 2.7 mg/g compared to 3.4 +/- 0.5 mg/g in wild-type mice

respiratory system
• signs of inflammation including goblet cell hyperplasia and inflammatory infiltrate in perivascular regions

endocrine/exocrine glands
• intrahepatic bile ducts

integument
• by 6 weeks of age some mice develop skin lesions on their ears and by 8 weeks of age all mice have these lesions
• inflammation contains a predominantly eosinophilic and lymphocytic inflitrate

cellular
• following TCR stimulation; however, in the absence of stimulation cells do not divide (similar to wild-type cells)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory