mortality/aging
• some mice die shortly after weaning
• dramatic decrease in survival beginning around 10 weeks of age with no mice survive more than 14 weeks
|
immune system
• spleen to body weight ratio is 16.9 +/- 2.7 mg/g compared to 3.4 +/- 0.5 mg/g in wild-type mice
|
• more T cells express CD4 and are activated
|
• following TCR stimulation; however, in the absence of stimulation cells do not divide (similar to wild-type cells)
|
• in Th2-polarizing conditions T cells are more likely to produce IL-4 compared to wild-type cells
|
• signs of inflammation including goblet cell hyperplasia and inflammatory infiltrate in perivascular regions
|
dermatitis
(
J:116617
)
• by 6 weeks of age some mice develop skin lesions on their ears and by 8 weeks of age all mice have these lesions
• inflammation contains a predominantly eosinophilic and lymphocytic inflitrate
|
hematopoietic system
• spleen to body weight ratio is 16.9 +/- 2.7 mg/g compared to 3.4 +/- 0.5 mg/g in wild-type mice
|
• seen in the liver and spleen
|
• bone marrow contains fewer B cells, more myeloid lineage cells, and similar numbers of pre-erythroid cells compared to wild-type mice
|
• more T cells express CD4 and are activated
|
• following TCR stimulation; however, in the absence of stimulation cells do not divide (similar to wild-type cells)
|
• in Th2-polarizing conditions T cells are more likely to produce IL-4 compared to wild-type cells
|
liver/biliary system
• intrahepatic bile ducts
|
• intrahepatic bile ducts
|
• liver to body weight ratio is 101 +/- 11 mg/g compared to 48 +/- 4 mg/g in wild-type mice
|
limbs/digits/tail
• tail becomes segmented in appearance over time
|
short tail
(
J:116617
)
• tails tend to be shorter
|
growth/size/body
• liver to body weight ratio is 101 +/- 11 mg/g compared to 48 +/- 4 mg/g in wild-type mice
|
• spleen to body weight ratio is 16.9 +/- 2.7 mg/g compared to 3.4 +/- 0.5 mg/g in wild-type mice
|
respiratory system
• signs of inflammation including goblet cell hyperplasia and inflammatory infiltrate in perivascular regions
|
endocrine/exocrine glands
• intrahepatic bile ducts
|
integument
dermatitis
(
J:116617
)
• by 6 weeks of age some mice develop skin lesions on their ears and by 8 weeks of age all mice have these lesions
• inflammation contains a predominantly eosinophilic and lymphocytic inflitrate
|
cellular
• following TCR stimulation; however, in the absence of stimulation cells do not divide (similar to wild-type cells)
|