Analysis Tools
liver/biliary system
|
• significantly increased in liver of mutants on a high fat/high cholesterol diet, compared to wild-type controls
|
|
• significantly increased in liver of mutants on a high fat/high cholesterol diet, compared to wild-type controls
|
|
• lipid accumulation is greater in mutant livers than in controls
|
respiratory system
|
• on a high fat/high cholesterol diet for 9 weeks, lungs exhibit irregular surfaces containing large crevices: on regular chow diet, lungs of mutants >15 weeks of age show presence of lipids
• pale foci indicative of lipid accumulation are visible
• chow-fed mice have giant cells, multiple lymphocytes and lipid positive macrophages in the lungs at 6 months of age
• subpleural region shows massive neutral lipid accumulation, and presence of many cholesterol clefts, multinucleated giant cells, and lymphocytes
|
|
• significantly increased in lungs of mutants on a high fat/high cholesterol diet, compared to wild-type controls
|
homeostasis/metabolism
|
• significantly increased in liver of mutants on a high fat/high cholesterol diet, compared to wild-type controls
|
|
• significantly increased in lungs of mutants on a high fat/high cholesterol diet, compared to wild-type controls
|
|
• phospholipid levels are significantly increased in liver and lungs of mutants on a high fat/high cholesterol diet, compared to wild-type controls
|
|
• significantly increased in lungs of mutants on a high fat/high cholesterol diet, compared to wild-type controls
|
|
• significantly increased in liver of mutants on a high fat/high cholesterol diet, compared to wild-type controls
|
immune system
|
• macrophage foam cells are present in subpleural region, containing lipid droplets and cholesterol clefts
|
|
• macrophage foam cells contain lipid droplets and many cholesterol clefts, suggesting defects in normal cholesterol processing; some macrophages also contain pneumocyte type II alveolar cells
• efflux of cholesterol to endogenous lipid receptors like HDL an apoA1 is impaired when macrophages are treated with LXR/RXR ligands
|
renal/urinary system
| N |
• kidneys of mutants do not show lipid accumulation, glomerulonephritis, or inflammatory cell infiltration
|
hematopoietic system
|
• macrophage foam cells are present in subpleural region, containing lipid droplets and cholesterol clefts
|
|
• macrophage foam cells contain lipid droplets and many cholesterol clefts, suggesting defects in normal cholesterol processing; some macrophages also contain pneumocyte type II alveolar cells
• efflux of cholesterol to endogenous lipid receptors like HDL an apoA1 is impaired when macrophages are treated with LXR/RXR ligands
|
cellular
|
• macrophage foam cells are present in subpleural region, containing lipid droplets and cholesterol clefts
|
