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Phenotypes Associated with This Genotype
Genotype
MGI:3695387
Allelic
Composition		 \Tg(CD2-LAT2)1Wz/0
Genetic
Background		 Not Specified
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No mouse lines available in IMSR.
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD8-positive, alpha-beta T cell physiology ( J:116157 )
• isolated cells produce very little IL-2, IL-10, TNFA, and IFNG after stimulation with PMA and ionomycin

hematopoietic system
abnormal CD8-positive, alpha-beta T cell physiology ( J:116157 )
• isolated cells produce very little IL-2, IL-10, TNFA, and IFNG after stimulation with PMA and ionomycin

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory