Phenotypes Associated with This Genotype

Genotype
MGI:3695219

• Allelic Composition: Tg(CD2-Ceacam1*4L)1Rsb/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased T cell number ( J:116136 )

• a decrease in CD3+ T cell population in total splenocytes is observed

abnormal T cell physiology ( J:116136 )

• transgene expression increases the amount of Ceacam1 on the surface of transgenic cells in the thymus and in peripheral lymph nodes, but not in intestinal epithelial lymphocytes (iIEL)

• cells are less responsive than wild-type cells in a mixed lymphocyte response (MLR) assay

• cells exhibit decreased contact sensitivity response to oxazolone

decreased T cell proliferation ( J:116136 )

• cells show lower proliferation compared to wild-type

immune system

decreased T cell number ( J:116136 )

• a decrease in CD3+ T cell population in total splenocytes is observed

abnormal T cell physiology ( J:116136 )

• transgene expression increases the amount of Ceacam1 on the surface of transgenic cells in the thymus and in peripheral lymph nodes, but not in intestinal epithelial lymphocytes (iIEL)

• cells are less responsive than wild-type cells in a mixed lymphocyte response (MLR) assay

• cells exhibit decreased contact sensitivity response to oxazolone

decreased T cell proliferation ( J:116136 )

• cells show lower proliferation compared to wild-type

decreased interleukin-2 secretion ( J:116136 )

• transgenic T cells produce less IL-2 than wild-type with anti-CD3 and -CD28 stimulation

cellular

decreased T cell proliferation ( J:116136 )

• cells show lower proliferation compared to wild-type