Analysis Tools
immune system
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• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle
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• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia
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• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days
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• decreased total lymphocyte counts in bronchoalveolar lavage after bleomycin injury
• reduced numbers of CD8+ T cells after bleomycin injury
• reduced numbers of NK cells at day 7 after bleomycin injury, but also in the lungs of unchallenged mice
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• increased cardiac allograft survival
• grafts with fewer Cd4+ and Cd8+ T cells
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respiratory system
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• decreased total lymphocyte counts in bronchoalveolar lavage after bleomycin injury
• reduced numbers of CD8+ T cells after bleomycin injury
• reduced numbers of NK cells at day 7 after bleomycin injury, but also in the lungs of unchallenged mice
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• more severe and extensive interstitial fibrosis in response to bleomycin injury
• increased collagen deposition by day 21
• 50% mortality
• treatment with exogenous IFN-gamma partially alleviates tissue fibrosis
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cardiovascular system
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• ischemic capillary density relative to nonischemic density 1.4 fold lower than in controls
• poor recovery of blood flow after ischemia
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homeostasis/metabolism
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• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days
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cellular
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• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle
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• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia
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hematopoietic system
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• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle
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• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia
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