Phenotypes Associated with This Genotype

Genotype
MGI:3694806

• Allelic Composition: Tg(IghelMD4)4Ccg/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased pro-B cell number ( J:115059 )

• bone marrow contains fewer combined numbers of combined pro-pre B cells than on a B6 background

decreased pre-B cell number ( J:115059 )

• bone marrow contains fewer combined numbers of combined pro-pre B cells than on a B6 background

abnormal B cell activation ( J:73608 )

• B cells become activated when cultured with HEL protein and CD4 T cells from Tg(TcrHEL3A9)1Mmd transgenic mice

• B cells in this culture quickly upregulate CD44 and CD86

• by 48 hours in culture, B cells are greatly enlarged as they undergo blastogenesis

• B cells cultured without the T cells initially upregulate activation markers but then die

• when HEL peptide is used in culture, some B cells increase expression of activation markers but do not form large blast cells

hematopoietic system

decreased pro-B cell number ( J:115059 )

• bone marrow contains fewer combined numbers of combined pro-pre B cells than on a B6 background

decreased pre-B cell number ( J:115059 )

• bone marrow contains fewer combined numbers of combined pro-pre B cells than on a B6 background

abnormal B cell activation ( J:73608 )

• B cells become activated when cultured with HEL protein and CD4 T cells from Tg(TcrHEL3A9)1Mmd transgenic mice

• B cells in this culture quickly upregulate CD44 and CD86

• by 48 hours in culture, B cells are greatly enlarged as they undergo blastogenesis

• B cells cultured without the T cells initially upregulate activation markers but then die

• when HEL peptide is used in culture, some B cells increase expression of activation markers but do not form large blast cells