Phenotypes Associated with This Genotype

Genotype
MGI:3694781

• Allelic Composition: Ranbp2^{Gt(pGT0pfs)630Wcs}/Ranbp2⁺
• Genetic Background: 129P2/OlaHsd-Ranbp2^{Gt(pGT0pfs)630Wcs}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain physiology ( J:116134 )

• Background Sensitivity: reduced levels of ATP in the brain and retina only in mice on an inbred 129P2/OlaHsd background and not in mice on a mixed 129P2/OlaHsd and C57BL/6J background

vision/eye

abnormal rod electrophysiology ( J:116134 )

• reduced a-wave and b-wave amplitudes

• reduction in b-wave responses is greater than that in a-wave responses

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:116134 )

• Background Sensitivity: slower weight gain beginning around 4 months of age when on a high fat diet only in mice on an inbred 129P2/OlaHsd background and not in mice on a mixed 129P2/OlaHsd and C57BL/6J background

• however, no differences in food consumption are detected

impaired glucose tolerance ( J:116134 )

• Background Sensitivity: reduced rates of glucose clearance only in mice on an inbred 129P2/OlaHsd background and not in mice on a mixed 129P2/OlaHsd and C57BL/6J background

• however, gluconeogenesis is similar to wild-type mice

growth/size/body

decreased susceptibility to diet-induced obesity ( J:116134 )

• Background Sensitivity: slower weight gain beginning around 4 months of age when on a high fat diet only in mice on an inbred 129P2/OlaHsd background and not in mice on a mixed 129P2/OlaHsd and C57BL/6J background

• however, no differences in food consumption are detected