Phenotypes Associated with This Genotype

Genotype
MGI:3694739

• Allelic Composition: Apba1^tm1.1Sud/Apba1^tm1.1Sud; Apba2^tm1.1Sud/Apba2^tm1.1Sud; Apba3^tm1.1Sud/Apba3^tm1.1Sud
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:115573 )

• triple mutants display survival deficit, with only ~20% survival postnatal

• hours after birth, pups have no milk in their stomachs, become progressively weaker within twelve hours, and die within 24 hours

nervous system

abnormal CNS synaptic transmission ( J:115573 )

• mice display decreased basal synaptic strength compared to Apba1-null mice

• in culture, when neonatal neurons homozygous for floxed Apba1, Apba2 and Apba3 alleles are treated with lentiviral cre, a ~30% reduction in miniature spontaneous current frequency in both excitatory and inhibitory synapses compared to control neurons

• synaptic response to hypertonic sucrose application is significantly decreased

abnormal inhibitory postsynaptic currents ( J:115573 )

• in response to hypertonic sucrose, currents are decreased ~45% in cultured, cre-treated neurons

• use-dependent depression in initially decreased at excitatory synapses during repetitive 10 Hz stimulation