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Phenotypes Associated with This Genotype
Genotype
MGI:3694708
Allelic
Composition		 Cr2tm1Crr/Cr2tm1Crr
Ggta1tm1Jbl/Ggta1tm1Jbl
Genetic
Background		 involves: 129S2/SvPas * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr2tm1Crr mutation (0 available); any Cr2 mutation (84 available)
Ggta1tm1Jbl mutation (2 available); any Ggta1 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal humoral immune response ( J:113488 )
• double mutants do not produce alpha-Gal-reactive natural antibodies; Ggta1-null and double mutants given anti alpha-Gal serumproduce similar levels of BSA-specific IgG antibodies after alpha-Gal immunization, indicating that complement receptors are not required to produce increased carrier immunogenicity
• elevated BSA immunogenicity in mutants is directly related to alpha-Gal specific antibodies

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory