Phenotypes Associated with This Genotype

Genotype
MGI:3694630

• Allelic Composition: Dbx1^tm1Tmj/Dbx1^tm1Tmj
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:70191 )

• homozygotes born in expected numbers but die at birth

nervous system

abnormal GABAergic neuron morphology ( J:70191 )

• increased numbers of lateral GABA expressing neurons

abnormal ventral interneuron 0 morphology ( J:70191 , J:89813 )

• V0v interneurons transform into a form somewhat like V1 interneurons (J:70191)

• axons project ipsilaterally but fail to project to the floor plate (J:70191)

• V0d interneurons transform into a form somewhat like dl6 interneurons (J:89813)

abnormal somatic nervous system physiology ( J:89813 )

• alternate right left pattern of motor activity of spinal nerves is inconsistent

• variability in the onset of contralateral step cycles disrupts the strict alternation of motor activity in L2 and L5 motor roots

• flexor-extensor coordination preserved however