Phenotypes Associated with This Genotype

Genotype
MGI:3694482

• Allelic Composition: Pdgfra^tm5Sor/Pdgfra^{tm11(EGFP)Sor}
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal oligodendrocyte morphology ( J:73817 )

• oligodendrocyte progenitor cell (OPC) migration away from their point of origin in the ventricular zone is inhibited between E12.5 and E13.5; although some OPCs eventually migrate out from the ventricular zone, they fail to evenly populate the spinal cord by the end of embryogenesis when myelination begins

decreased oligodendrocyte progenitor number ( J:73817 )

• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis

cellular

abnormal oligodendrocyte morphology ( J:73817 )

• oligodendrocyte progenitor cell (OPC) migration away from their point of origin in the ventricular zone is inhibited between E12.5 and E13.5; although some OPCs eventually migrate out from the ventricular zone, they fail to evenly populate the spinal cord by the end of embryogenesis when myelination begins

decreased oligodendrocyte progenitor number ( J:73817 )

• the oligodendrocyte progenitor cell population is reduced throughout embryogenesis