Phenotypes Associated with This Genotype

Genotype
MGI:3694472

• Allelic Composition: Pdgfra^tm6Sor/Pdgfra^tm6Sor
• Genetic Background: either: 129S4/SvJaeSor-Pdgfra^tm6Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:73817 )

• 60% die by P35, although a few survive for over 12 months

nervous system

seizures ( J:73817 )

• Background Sensitivity: exhibit spontaneous seizures that are more severe on a mixed 129S4/SvJaeSor and C57BL/6J background than on a coisogenic 129S4/SvJaeSor background

abnormal myelination ( J:73817 )

• most regions of the CNS displays severe hypomyelination

behavior/neurological

tremors ( J:73817 )

• Background Sensitivity: exhibit shaking; phenotype is more severe on a mixed 129S4/SvJaeSor and C57BL/6J background than on a coisogenic 129S4/SvJaeSor background

abnormal locomotor coordination ( J:73817 )

• decrease in limb mobility

seizures ( J:73817 )

• Background Sensitivity: exhibit spontaneous seizures that are more severe on a mixed 129S4/SvJaeSor and C57BL/6J background than on a coisogenic 129S4/SvJaeSor background

skeleton

skeleton phenotype ( J:73817 )

N • do not exhibit skeletal defects

craniofacial

craniofacial phenotype ( J:73817 )

N • do not exhibit cleft palate