Phenotypes Associated with This Genotype

Genotype
MGI:3694362

• Allelic Composition: Ube3a^tm1Alb/Ube3a⁺
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

audiogenic seizures ( J:50811 )

• Background Sensitivity: observed in 18% of mice with paternal deficiency and 85% (17/20) with maternal deficiency compared to mice on 129/B6 background

• mice with maternal deficiency are susceptible to audiogenic seizures characterized by running and leaping followed by tonic clonic seizures

tonic-clonic seizures ( J:50811 )

• occasionally observed in mice with maternal deficiency

nervous system

audiogenic seizures ( J:50811 )

• Background Sensitivity: observed in 18% of mice with paternal deficiency and 85% (17/20) with maternal deficiency compared to mice on 129/B6 background

• mice with maternal deficiency are susceptible to audiogenic seizures characterized by running and leaping followed by tonic clonic seizures

tonic-clonic seizures ( J:50811 )

• occasionally observed in mice with maternal deficiency