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Phenotypes Associated with This Genotype
Genotype
MGI:3694085
Allelic
Composition		 Atp1a2tm2Ling/Atp1a2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a2tm2Ling mutation (0 available); any Atp1a2 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle contractility ( J:114415 )
• in isometric measurements of isolated EDL muscle, more force is produced at any given voltage, and has higher force is at supramaximal voltage compared to wild-type; peak tetanic force is 384 mN/sq. mm compared to 297 mN/sq. mm in wild-type
• rate of force development in tetanic contraction is significantly increased compared to wild-type
• EDL twitch force is 34% higher than that produced by wild-type
• constant for fatigue is similar to wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory