Phenotypes Associated with This Genotype

Genotype
MGI:3694083

• Allelic Composition: Mfge8^tm1Osa/Mfge8^tm1Osa
• Genetic Background: B6.129-Mfge8^tm1Osa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:103839 )

♀ • reduced ability of epithelial cells of involuting mammary glands to engulf apoptotic cells

♀ • 2-3 times more apoptotic cells found in the involuting mammary gland than in controls after 2 days

♀ • at day 4 of involution, alveoli of involuting glands with enlarged lumina containing cell debris

♀ • enlarged debris filled ducts still present at day 10

abnormal mammary gland growth during lactation ( J:103839 )

♀ • redevelopment of mammary glands is abnormal due to defects in involution process

♀ • presence of fat pads as well as abnormal ducts and alveoli interfere with redevelopment

abnormal milk composition ( J:103839 )

♀ • reduced production of milk proteins

hypolactation ( J:103839 )

♀ • decreased milk production

integument

abnormal involution of the mammary gland ( J:103839 )

♀ • reduced ability of epithelial cells of involuting mammary glands to engulf apoptotic cells

♀ • 2-3 times more apoptotic cells found in the involuting mammary gland than in controls after 2 days

♀ • at day 4 of involution, alveoli of involuting glands with enlarged lumina containing cell debris

♀ • enlarged debris filled ducts still present at day 10

abnormal mammary gland growth during lactation ( J:103839 )

♀ • redevelopment of mammary glands is abnormal due to defects in involution process

♀ • presence of fat pads as well as abnormal ducts and alveoli interfere with redevelopment

abnormal milk composition ( J:103839 )

♀ • reduced production of milk proteins

hypolactation ( J:103839 )

♀ • decreased milk production

immune system

immune system phenotype ( J:187181 )

N • Background Sensitivity: mice exhibit normal autoantibody levels when backcrossed to C57BL/6 for more than 8 generations