Phenotypes Associated with This Genotype

Genotype
MGI:3694056

• Allelic Composition: Npy2r^tm1Hhz/Npy2r^tm1Hhz
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:77345 )

N • at 34 days after injection, leptinemia, insulinemia and glycemia are not significantly different from controls

abnormal circulating hormone level ( J:77345 )

increased circulating corticosterone level ( J:77345 , J:97455 )

• in mice treated with a hypothalamus-specific cre (J:97455)

♂ • male, but not female hypothalamus-specific null mice, display corticosteronemia at 34 days post-injection (J:77345)

abnormal circulating insulin level ( J:77345 )

• at 12 days post-injection, insulinemia of hypothalamus-specific mutants tend toward lower values (58) than controls (97)

increased circulating pancreatic peptide level ( J:77345 )

♂ • male, but not female, hypothalamus-specific knockouts show a four-fold increase in plasma pancreatic polypeptide (PP) levels 34 days after injection

skeleton

decreased osteoclast cell number ( J:97455 )

• in mice treated with a hypothalamus-specific cre

abnormal trabecular bone morphology ( J:97455 )

• in mice treated with a hypothalamus-specific cre, trabecular bone volume is increased 2-fold compared to in control mice

• in mice treated with a hypothalamus-specific cre, trabeculae number and thickness are increased compared to in control mice

increased trabecular bone thickness ( J:97455 )

• in mice treated with a hypothalamus-specific cre

increased bone mineralization ( J:97455 )

• in mice treated with a hypothalamus-specific cre, bone mineral apposition rate is increased 2-fold compared to in control mice

increased bone ossification ( J:97455 )

• in mice treated with a hypothalamus-specific cre, bone formation rate is increased 2-fold compared to in control mice

growth/size/body

decreased body weight ( J:77345 )

• 7-8 days after hypothalamic cre-recombinase injection, mutants display a drop in body weight compared to GFP-injected mice or cre-injected wild-type mice or mutants receiving cre injection in the CA3 region of the hippocampus; at 12 days post-injection, hypothalamus-specific null mutants weigh significantly less than controls

• recovery to initial body weight is significantly delayed in hypothalamus-specific null mice; male controls return to original body weight within 14-22 days, but male hypothalamic-null mice do not fully recover their body weight until 28 days while null females recover by 23 days post-injection compared to 16 days in control females

adipose tissue

adipose tissue phenotype ( J:77345 )

N • hypothalamus-specific null mice do not show differences in white adipose tissue mass compared to controls

behavior/neurological

abnormal food intake ( J:77345 )

• male hypothalamus-specific null mice show significantly greater food intake than control mice after cre injection; female hypothalamus-null mutants show a similar tendency toward increased food intake

hematopoietic system

decreased osteoclast cell number ( J:97455 )

• in mice treated with a hypothalamus-specific cre

immune system

decreased osteoclast cell number ( J:97455 )

• in mice treated with a hypothalamus-specific cre