Phenotypes Associated with This Genotype

Genotype
MGI:3693951

• Allelic Composition: Npy2r^tm1.1Hhz/Npy2r^tm1.1Hhz
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:124729 )

• kainic acid-exposed mice over-expressing rAAV1/2-NPY exhibit an increase in mortality compared with similarly treated wild-type mice

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:124729 )

• mice exhibit a higher proportion of time in motor seizures induced by the over-expression of rAAV1/2-NPY compared with wild-type mice

• however, mice expressing rAAV1/2 empty vector exhibit normal seizure response

• kainic acid-exposed mice over-expressing rAAV1/2-NPY exhibit an increase in mortality compared with similarly treated wild-type mice

impaired long-term object recognition memory ( J:121312 )

• 1 and 6 hours after initial exposure, mice exhibit deteriorating object recognition compared with wild-type mice

abnormal spatial learning ( J:121312 )

• in a probe trial, mice make fewer passes over and spend less time at the original platform position compared with similarly treated wild-type mice

• however, swim speed and visible platform performance are normal

increased fluid intake ( J:115774 )

• mutants drink significantly more during the dark phase compared to controls

• total 24 hour water intake is significantly increased during the 3 day observation period

• this behavior is maintained following injection of physiological saline (vehicle). beta-adrenoreceptor antagonist propanolol, or angiotensin AT1 receptor antagonist telmisartan

abnormal eating behavior ( J:77345 )

• in male mice at 8 weeks but not 12 weeks

• in female mice at 8 and 12 weeks

decreased anxiety-related response ( J:96222 )

• in an elevated plus maze, mice make more entries and spend more time in open arms compared with wild-type mice

• in an open field test, mice exhibit a preference for the central area unlike wild-type mice

homeostasis/metabolism

decreased circulating corticosterone level ( J:107169 )

• level is attenuated compared to wild-type (64 ng/ml vs 102 ng/ml in wild-type)

decreased circulating insulin level ( J:77345 )

♂ • in corticosterone treated male mice

increased circulating insulin-like growth factor I level ( J:129609 )

• after fasting compared with similarly treated wild-type mice

increased circulating pancreatic peptide level ( J:77345 )

♂ • increased 3-fold in male mice

increased growth hormone level ( J:129609 )

• pituitary gland cell growth hormone levels are increased in fasting mice compared to non-fasting mice and unlike in similarly treated wild-type mice

abnormal testosterone level ( J:129609 )

• testosterone levels in Leydig cells are increased in fasting mice compared to in similarly treated wild-type mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:124729 )

• kainic acid-exposed mice over-expressing rAAV1/2-NPY exhibit an increase in mortality compared with similarly treated wild-type mice

nervous system

increased susceptibility to pharmacologically induced seizures ( J:124729 )

• mice exhibit a higher proportion of time in motor seizures induced by the over-expression of rAAV1/2-NPY compared with wild-type mice

• however, mice expressing rAAV1/2 empty vector exhibit normal seizure response

• kainic acid-exposed mice over-expressing rAAV1/2-NPY exhibit an increase in mortality compared with similarly treated wild-type mice

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice

abnormal rostral migratory stream morphology ( J:132859 )

• fewer proliferating cells are found in the subventricular zone and migratory rostral stream compared to in wild-type mice

• fewer DC+ cells are located in the subventricular zone and rostral migratory stream than in wild-type mice

abnormal postnatal subventricular zone morphology ( J:132859 )

• fewer proliferating cells are found in the subventricular zone leading to fewer migrating neuroblasts compared to in wild-type mice

• fewer DC+ cells are located in the subventricular zone and rostral migratory stream than in wild-type mice

decreased neuronal precursor cell number ( J:132859 )

• fewer proliferating cells are found in the subventricular zone and migratory rostral stream compared to in wild-type mice

• fewer DC+ cells are located in the subventricular zone and rostral migratory stream than in wild-type mice

skeleton

abnormal trabecular bone morphology ( J:97455 )

• trabecular bone volume is increased 2-fold compared to in wild-type mice

• trabeculae number and thickness are increased compared to in wild-type mice

increased trabecular bone thickness ( J:97455 )

growth/size/body

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice

decreased body weight ( J:77345 )

• beginning at 4 weeks of age and continuing for the 16 week monitoring period

adipose tissue

decreased white adipose tissue amount ( J:77345 )

♂ • in male mice regardless of corticosterone treatment

craniofacial

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice

respiratory system

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:132859 )

• fewer CR+ neurons are located in the glomerular and granular cell layers of the olfactory bulb compared to in wild-type mice

• fewer CB+ and TH+ neurons are located in the glomerular layer of the olfactory bulb compared to in wild-type mice