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Phenotypes Associated with This Genotype
Genotype
MGI:3693895
Allelic
Composition
Gucy2etm1Gar/Gucy2etm1Gar
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy2etm1Gar mutation (1 available); any Gucy2e mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• by 5 weeks of age, number of identifiable cones is dramatically reduced
• cells degenerate rapidly at 4-5 weeks of age, with few surviving at late stages
• by 1 month of age, electroretinograms (ERG) of mutant mice are abnormal
• at one month of age, cone responses to flashes in rod-saturating background are barely detectable
• rod a-wave and b-wave of ERG are severely reduced at one month of age
• flash response from a rod demonstrates increased time-to-peak before decaying more rapidly than in controls; rods have a higher sensitivity than wild-type
• rods show oscillations during and after recovery from a light flash

nervous system
• by 5 weeks of age, number of identifiable cones is dramatically reduced
• cells degenerate rapidly at 4-5 weeks of age, with few surviving at late stages

Mouse Models of Human Disease
OMIM ID Ref(s)
Cone-Rod Dystrophy 6; CORD6 601777 J:77627


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory