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Phenotypes Associated with This Genotype
Genotype
MGI:3693869
Allelic
Composition		 Pdgfrbtm5Sor/Pdgfrbtm5Sor
Genetic
Background		 either: 129S4/SvJaeSor-Pdgfratm5Sor or (involves: 129S4/SvJaeSor * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrbtm5Sor mutation (0 available); any Pdgfrb mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:67735 )
• the heart-to-body weight ratio exceeds controls by 26%

homeostasis/metabolism
abnormal glomerular capillary thrombosis ( J:67735 )
• in a model of crescentic glomerulonephritis, mutants fail to resolve the glomerular injury and show formation of thrombus that is not observed in wild-type
increased susceptibility to injury ( J:67735 )
• in a model of crescentic glomerulonephritis, mutants fail to resolve the glomerular injury and show formation of thrombus that is not observed in wild-type

growth/size/body
enlarged heart ( J:67735 )
• the heart-to-body weight ratio exceeds controls by 26%

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory