Phenotypes Associated with This Genotype

Genotype
MGI:3693372

• Allelic Composition: Fyn^tm1Sor/Fyn^tm1Sor; Tg(Camk2a-Fyn)1Kndl/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus morphology ( J:80637 )

• do not exhibit rescue of the morphological defects of the hippocampus that are seen in single Fyn homozygotes, however Schaffer collateral LTP is restored

abnormal dentate gyrus morphology ( J:80637 )

• dorsal part of the dentate gyrus granular cell layer is occasionally perturbed

abnormal hippocampus pyramidal cell layer ( J:80637 )

• caudal part of CA3 pyramidal cell layer is undulated and CA1 pyramidal cells are less tightly packed

abnormal hippocampus pyramidal cell morphology ( J:80637 )

• dendritic regions of pyramidal cells are narrow and length of the apical dendrites is shortened

ectopic hippocampus pyramidal cells ( J:80637 )

• ectopic pyramidal cells are frequently seen