Phenotypes Associated with This Genotype

Genotype
MGI:3693333

• Allelic Composition: Tg(Camk2a-Fyn-531)1Nko/0
• Genetic Background: B6.Cg-Tg(Camk2a-Fyn-531)1Nko

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

alcohol aversion ( J:79980 )

• 40% reduction in voluntary alcohol intake

impaired behavioral response to alcohol ( J:79980 )

• exhibit resistance against alcohol withdrawal-induced behavior; whereas wild-type show reduced exploration of the light compartment and fewer transitions between light and dark after alcohol discontinuation, mutants show normal exploratory behavior, similar to that seen in non-alcohol treated wild-type mice

decreased behavioral withdrawal response ( J:79980 )

• exhibit resistance against alcohol withdrawal-induced behavior; whereas wild-type show reduced exploration of the light compartment and fewer transitions between light and dark after alcohol discontinuation, mutants show normal exploratory behavior, similar to that seen in non-alcohol treated wild-type mice

decreased anxiety-related response ( J:79980 )

• following alcohol withdrawal, mutants do not show the pronounced anxiety-like behavior seen in wild-type controls

abnormal locomotor behavior ( J:79980 )

• following alcohol withdrawal, mutant mice show unaltered exploratory behavior in light/dark box test, unlike wild-type that show decreased locomotor activity