Phenotypes Associated with This Genotype

Genotype
MGI:3693305

• Allelic Composition: Grin1^tm1Yql/Grin1^tm1Yql; Rgs9^{tm1.1(cre)Yql}/Rgs9⁺
• Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor learning ( J:115299 )

• in rotarod tests, mutants do not show increased duration on rotating rod with successive trials, but control mice do; performance by wild-type on final 3 trials is significantly better than mutants which show impaired motor learning

nervous system

abnormal medium spiny neuron morphology ( J:115299 )

• medium spiny neurons have higher primary dendrite numbers (8.2) compared to wild-type (7)

abnormal excitatory postsynaptic currents ( J:115299 )

• NMDA-receptor mediated EPSCs are nearly abolished in mutants compared to wild-type

abnormal NMDA-mediated synaptic currents ( J:115299 )

• density of current activated by NMDA is reduced greatly in mutants vs controls

reduced long-term potentiation ( J:115299 )

• after high frequency stimulation, dorsomedial striatal slices from mutants do not display LTP

absent long-term depression ( J:115299 )

• brain slices that include the nucleus accumbens (NAc) from mutant mice do not show LTD with moderate-frequency stimulation of the NAc