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Phenotypes Associated with This Genotype
Genotype
MGI:3693295
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• by 4-5 months of age, defects in Y-maze alternation are detected in transgenic mice, indicating impaired spatial learning/memory

nervous system
• mice show Abeta42 deposits at 2 months of age; Abeta40 levels are lower in amyloid deposits; mice show robust intraneuronal amyloid deposition
• amyloid deposition increases rapidly with increasing age
• plaques appear first in deep cortical layers and in subiculum, and spread with age to fill most of cortex, subiculum and hippocampus; also, less numerous deposits are observed in thalamus, brainstem and olfactory bulb in older mice
• transgenic mice display neuroinflammation
• cortical layer 1 is significantly thinner than in control brains
• neurons in subiculum are very pale, or absent
• microgliosis and astrogliosis is seen in plaque-bearing regions of the brain by 2 months of age; numbers of activated astrocytes and microglia increases with age
• some neurons contain intraneuronal aggregates and display disrupted morphology
• large neurons in cortical layer 5 are reduced in number
• synapse degeneration begins at 4 months of age, compared to nontransgenic controls, as shown by reduction in levels of synaptic markers; neurodeneration marker p25 level is ~150% of control at 9 and 12 months

immune system
• transgenic mice display neuroinflammation

homeostasis/metabolism
• mice show Abeta42 deposits at 2 months of age; Abeta40 levels are lower in amyloid deposits; mice show robust intraneuronal amyloid deposition
• amyloid deposition increases rapidly with increasing age
• plaques appear first in deep cortical layers and in subiculum, and spread with age to fill most of cortex, subiculum and hippocampus; also, less numerous deposits are observed in thalamus, brainstem and olfactory bulb in older mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:112949
Alzheimer Disease; AD 104300 J:112949


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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory