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Phenotypes Associated with This Genotype
Genotype
MGI:3693295
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• by 4-5 months of age, defects in Y-maze alternation are detected in transgenic mice, indicating impaired spatial learning/memory (J:112949)
• by 4-5 months of age, defects in Y-maze alternation are detected in transgenic mice, indicating impaired spatial learning/memory (J:112949)

nervous system
• mice show Abeta42 deposits at 2 months of age; Abeta40 levels are lower in amyloid deposits; mice show robust intraneuronal amyloid deposition (J:112949)
• amyloid deposition increases rapidly with increasing age (J:112949)
• plaques appear first in deep cortical layers and in subiculum, and spread with age to fill most of cortex, subiculum and hippocampus; also, less numerous deposits are observed in thalamus, brainstem and olfactory bulb in older mice (J:112949)
• mice show Abeta42 deposits at 2 months of age; Abeta40 levels are lower in amyloid deposits; mice show robust intraneuronal amyloid deposition (J:112949)
• amyloid deposition increases rapidly with increasing age (J:112949)
• plaques appear first in deep cortical layers and in subiculum, and spread with age to fill most of cortex, subiculum and hippocampus; also, less numerous deposits are observed in thalamus, brainstem and olfactory bulb in older mice (J:112949)
• transgenic mice display neuroinflammation (J:112949)
• transgenic mice display neuroinflammation (J:112949)
• cortical layer 1 is significantly thinner than in control brains (J:112949)
• cortical layer 1 is significantly thinner than in control brains (J:112949)
• neurons in subiculum are very pale, or absent (J:112949)
• neurons in subiculum are very pale, or absent (J:112949)
• microgliosis and astrogliosis is seen in plaque-bearing regions of the brain by 2 months of age; numbers of activated astrocytes and microglia increases with age (J:112949)
• microgliosis and astrogliosis is seen in plaque-bearing regions of the brain by 2 months of age; numbers of activated astrocytes and microglia increases with age (J:112949)
• some neurons contain intraneuronal aggregates and display disrupted morphology (J:112949)
• some neurons contain intraneuronal aggregates and display disrupted morphology (J:112949)
• large neurons in cortical layer 5 are reduced in number (J:112949)
• large neurons in cortical layer 5 are reduced in number (J:112949)
• synapse degeneration begins at 4 months of age, compared to nontransgenic controls, as shown by reduction in levels of synaptic markers; neurodeneration marker p25 level is ~150% of control at 9 and 12 months (J:112949)
• synapse degeneration begins at 4 months of age, compared to nontransgenic controls, as shown by reduction in levels of synaptic markers; neurodeneration marker p25 level is ~150% of control at 9 and 12 months (J:112949)

immune system
• transgenic mice display neuroinflammation (J:112949)
• transgenic mice display neuroinflammation (J:112949)

homeostasis/metabolism
• mice show Abeta42 deposits at 2 months of age; Abeta40 levels are lower in amyloid deposits; mice show robust intraneuronal amyloid deposition (J:112949)
• amyloid deposition increases rapidly with increasing age (J:112949)
• plaques appear first in deep cortical layers and in subiculum, and spread with age to fill most of cortex, subiculum and hippocampus; also, less numerous deposits are observed in thalamus, brainstem and olfactory bulb in older mice (J:112949)
• mice show Abeta42 deposits at 2 months of age; Abeta40 levels are lower in amyloid deposits; mice show robust intraneuronal amyloid deposition (J:112949)
• amyloid deposition increases rapidly with increasing age (J:112949)
• plaques appear first in deep cortical layers and in subiculum, and spread with age to fill most of cortex, subiculum and hippocampus; also, less numerous deposits are observed in thalamus, brainstem and olfactory bulb in older mice (J:112949)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:112949
Alzheimer Disease; AD 104300 J:112949


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory